Effervescent Tablets Formulation of Jicama (Pachyrhizus erosus) Extract with Various Concentrations of Binders and Sweeteners

Osteoporosis is a major public health problem. Exogenous estrogen or Hormone Replacement Therapy (HRT) the potential therapy for osteoporosis. Still, patient rarely chooses this treatment because of risk breast and endometrial cancer. Phytoestrogens estrogen-like compounds, particularly isoflavones, are potentially safe alternative to HRT. Jicama (Pachyrhizus erosus) plant that contains many phytoestrogens. This research aimed determine physicochemical characteristics jicama extract in effervescent tablets with various concentrations binder sweetener. The manufacturing used raw materials extracted from 96% p.a. ethanol by maceration. then formulated (PVP 40 gelatin) sweeteners (lactose Mannitol) using wet granulation method. Based on test results properties tablets, all formula meets requirement good tablet, preferred Formula 4 0.75% PVP40 47,75% Mannitol. Ethanol can be into has developed as osteoporosis.
 Keywords: Xicama Extract, Fitoestrogen, Estrogen-like therapy, Osteoporosis, Effervescent tablet